Independent Studies Research Articles

Repeat it without me: Crowdsourcing the T1 mapping common ground via the ISMRM reproducibility challenge.

T1 mapping is a widely used quantitative MRI technique, but its tissue-specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research and Quantitative MR study groups jointly launched a challenge to assess the reproducibility of a well-established inversion-recovery T1 mapping technique, using acquisition details from a seminal T1 mapping paper on a standardized phantom and in human brains. The challenge used the acquisition protocol from Barral et al. (2010). Researchers collected T1 mapping data on the ISMRM/NIST phantom and/or in human brains. Data submission, pipeline development, and analysis were conducted using open-source platforms. Intersubmission and intrasubmission comparisons were performed. Eighteen submissions (39 phantom and 56 human datasets) on scanners by three MRI vendors were collected at 3 T (except one, at 0.35 T). The mean coefficient of variation was 6.1% for intersubmission phantom measurements, and 2.9% for intrasubmission measurements. For humans, the intersubmission/intrasubmission coefficient of variation was 5.9/3.2% in the genu and 16/6.9% in the cortex. An interactive dashboard for data visualization was also developed: https://rrsg2020.dashboards.neurolibre.org. The T1 intersubmission variability was twice as high as the intrasubmission variability in both phantoms and human brains, indicating that the acquisition details in the original paper were insufficient to reproduce a quantitative MRI protocol. This study reports the inherent uncertainty in T1 measures across independent research groups, bringing us one step closer to a practical clinical baseline of T1 variations in vivo.

Strategies for digital entrepreneurship success: the role of digital implementation and dynamic capabilities

PurposeTo augment sales revenue, B2B digital start-ups aim to create and sustain commercial relationships with industry incumbents. However, since these incumbents have traditionally struggled with implementing disruptive digital artifacts, most studies have almost exclusively concentrated on their challenges, leaving the digital start-ups' side underexplored. Therefore, this study seeks to understand how digital start-ups navigate digital implementation (DI) hardships to ultimately achieve digital entrepreneurship success.Design/methodology/approachAn abductive explanatory multi-case study of four industries that pose a variety of implementation challenges for B2B digital start-ups (agriculture, insurance, real estate and construction, and healthcare) was conducted using data collected from 40 interviews with Israeli experts and relevant digital data observations.FindingsThis study articulates two main observations. (1) Throughout their journeys, digital start-ups have utilized newly created and/or refined dynamic capabilities (DC) to successfully implement their digital artifacts. Simultaneously, successful DI has enabled digital start-ups to create new DC or sustain and evolve current DC. (2) We provide empirical evidence outlining how digital start-ups using continuous learning have combined causation and effectuation logic throughout their DI journeys.Originality/valueThis study answers a call to explore more explicit digital-related drivers (i.e. DI) for digital entrepreneurship success by studying a highly-ranked country on the Global Entrepreneurship Index (GEI) to achieve this. Moreover, it illustrates how digital start-ups evolve throughout their commercial relationships with industry incumbents, thereby enabling an effective approach for successful DI. Such an approach can be considered very valuable for both practitioners and policymakers. Consequently, it advances digital entrepreneurship as an independent research topic.

Hemodynamic effects of treatment with the ketone body 3-hydroxybutyrate in cardiogenic shock - a randomized, controlled, assessor-blinded porcine trial

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Novo Nordisk Foundation Independent Research Fund DK. Background Cardiogenic shock (CS) is a life-threatening disease with limited evidence-based treatment options. Treatment with the ketone body 3-hydroxybutyrate (3-OHB) induces favorable hemodynamic effects in patients with heart failure and CS. It increases cardiac output (CO) and left ventricular (LV) ejection fraction (LVEF) while reducing cardiac filling pressures. Yet, whether treatment with 3-OHB demonstrates beneficial hemodynamic effects during acute ischemic LV stunning in CS must be fully elucidated. This study aimed to examine the acute hemodynamic effects and underlying cardiovascular mechanisms of 3-OHB infusion in the acute phase of LV stunning in a porcine model of ischemic CS. Methods Sixteen 60-kg-pigs were included in a randomised, controlled, assessor-blinded crossover study. CS was achieved by repeated, slow injections of microspheres into the left main coronary artery. CS was defined as ≥30% reduction in CO and/or mixed venous saturation (SVO2). Upon the onset of CS, following a one-hour no-touch period, the pigs received an infusion with 3-OHB and isoosmolar, isovolumic saline (control) for two hours each in random order. Infusion periods were separated by a one-hour washout period. CO (primary endpoint), SVO2, and pulmonary pressures were measured by right heart catheterization. A pressure-volume admittance catheter was placed in the LV to measure LVEF, contractility (the slope of end systolic pressure-volume relationship, denoded as Ees), afterload (arterial elastance, Ea, and end-systolic pressure, ESP), preload (end-diastolic volume, EDV), and work-related parameters. Results CS was successfully achieved in all randomized animals. CO decreased by 36% from 4.5±1.0 L/min to 2.9±0.5 L/min (p<0.001) and SVO2 decreased by 31% from 55.0±8.1% to 37.7±5.8% (p<0.001). During 3-OHB infusion, CO increased by 0.9 L/min (95% CI: 0.4 to 1.3 L/min) compared with the control infusion. In parallel, Ees increased by 0.22 mmHg/mL (95% CI: 0.08 to 0.37 mmHg/mL), LVEF improved by 7 percentage points (95%CI: 1 to 13 percentage points) and cardiac efficiency increased by 6 percentage points (95%CI: 1 to 11 percentage points). Systemic vascular resistance was decreased by 479 dyn*cm5 (95% CI: 736 to 221 dyn*cm5); Ea and ESP remained similar. Heart rate was increased during 3-OHB infusion by 21 bpm (95% CI: 11 to 32 bpm) while no significant change was observed in stroke volume (p=0.6). Conclusion Treatment with 3-OHB improved CO, LVEF, and cardiac efficiency in CS. The increase was mediated through increased ventricular contractility and decreased peripheral resistance accompanied by increased heart rate.CO, Ees and cardiac efficiencyEndpoint parameters during 3-OHB

Exploring Pedagogical Adaptation Challenges Faced by Novice EFL Teachers in Higher Education: A Study from Hubei Province, China

The novice teachers encountered numerous challenges upon embarking on their careers in schools. The primary obstacles typically arose from the misalignment between their teaching abilities and the practical demands of their work. This study, focusing on novice EFL teachers in Hubei Province, addressed the following inquiries from the perspectives of the theory of teachers' career development stage and the theory of work adjustment:What were the challenges confronting novice EFL teachers regarding their teaching abilities in Higher Education Institutions in Hubei Province?What factors contributed to these challenges related to teaching capability?What approaches did novice teachers adopt to address these challenges?This study employed a qualitative approach, with three novice EFL teachers newly employed by three different institutions serving as informants. Data were gathered from teaching diaries, lesson plans, classroom observations, and interviews. The researchers identified and categorized challenges related to teaching capability and coping strategies mentioned in the diaries, corroborating them with data from other sources such as lesson plan reviews and classroom observations. Subsequently, the researchers conducted interviews to explore the underlying causes of these challenges and assess the effectiveness of the teachers' coping strategies.Based on the analysis of the qualitative data, the study draws the following conclusions:Novice EFL teachers encountered challenges across four dimensions: language proficiency, instructional design, classroom management, and feedback skills, as evidenced by data from language use, lesson structure, objective setting, and multimedia integration.The challenges stemmed from personal factors, contextual influences, and external interventions.Novice EFL teachers endeavored to address these challenges, often effectively, by integrating theoretical knowledge with practical experience, seeking guidance from experienced colleagues, engaging in peer consultation, and conducting independent research.

Linkage of routinely collected NHS data to evaluate liaison mental health services: challenges and lessons learned.

Liaison mental health services provide mental health care to patients in acute hospital settings. Evaluation of liaison services is challenging due to their heterogeneous organisation and delivery, high case throughput and varied patient case mix. We aimed to link routinely collected National Health Service data from secondary care settings, chosen for their service characteristics, to data from primary care to evaluate hospital-based liaison mental health services in England. We planned to compare patients referred to hospital-based liaison services with comparable patients in the same hospital not referred to liaison services and comparable patients in hospitals without any liaison services. We designed and enacted a methodology to link data from: (1) Hospital Episode Statistics, a database controlled by the National Health Service Digital and (2) ResearchOne, a primary care database controlled by The Phoenix Partnership. Obtaining approvals for the steps prespecified in the methodological protocol took 907 days. Enactment following approvals took 385 days. Data supplied from Hospital Episode Statistics contained 181,063 patients from 6 hospitals (mean=30,177, standard deviation=28,875.86) who matched the inclusion and exclusion criteria. Data supplied from ResearchOne contained 33,666 (18.6%) of these patients from the 6 hospitals (mean=5611, standard deviation=5206.59). Time required for approvals and enactment was attributable to slowness of data handling processes within each data holder and to resolution of technical and organisational queries between them. Variation in number of patients for which data was supplied between databases and between hospitals was attributable to coding inconsistencies and to the limited intersection of patient populations between databases and variation in recording practices between hospitals. Although it is technically feasible to link primary and secondary care data, the current system is challenging, complicated, unnecessarily bureaucratic, time consuming and costly. This limits the number of studies that could be conducted with these rich data sources. This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme as award number 13/58/08.

Learning to Learn Independently: Guiding Students to Develop Self-Directed Learning Skills During Medical Student Independent Research Projects—Findings from an Australian University

Abstract Introduction Most medical schools offer students the opportunity to conduct independent research projects in order to learn about evidence-based medicine. This study aimed to explore the experience of students, graduates, and supervisors during an independent research project through the lens of self-directed learning. Methods Students and recent graduates were asked to complete an anonymous survey about their experiences. Semi-structured interviews were also conducted with a purposeful sample of 11 students, 14 graduates, and 25 supervisors. Interviews were recorded and transcribed. An inductive thematic analysis was conducted and themes were refined through the lens of self-directed learning. Results Most participants agreed that the independent research project could enable students to develop valuable self-directed learning skills. Participants commented on the importance of the research mentor, faculty support structures, and membership of a research team. Participants who were not well supported described feeling distressed and isolated. Discussion Medical student involvement in independent research projects can develop self-directed learning skills in the presence of a one-to-one mentoring relationship with a research supervisor, structured guidelines and support from the faculty, and membership of a research team. The development of self-directed learning skills should be part of the learning outcomes of any independent student research project.

Innovation and Entrepreneurship Education Practice Reform for College Students Majoring in Food - Independent Intellectual Property Probiotics Research and Development as An Example

近年来，随着高等教育质量的不断提高，高校创新创业教育逐渐加强，并取得显著进展。这一教育模式在提升教育质量、促进学生全面发展、推动毕业生就业创业以及服务国家现代化建设方面发挥了重要作用。然而，创新创业教育在实施过程中也面临一些问题。本文针对现目前食品行业创新创业的问题，以自主知识产权益生菌项目为例提出了一系列措施，旨在为食品功能化、智能化和信息化发展培养合格的双创人才。

A Systematic Review of Dust Suppression Methods by Experiment Based on Intelligent Technology in the Coal Mines

The mining and its transportation processes generate a substantial quantity of dust, which harms miners' health. The extended inhalation of dust particles could result in pneumoconiosis. There are numerous studies on coal mine dust removal, but only a handful of articles critically comment on it. A systematic coal mine dedusting literature review has been conducted to attempt a comprehensive and reproducible analysis. This article reviews dust suppression methods by experiment in coal mines from three aspects: chemical modification of dust removers, structural improvement of dust removers, and other factors. The review showed that independent experimental research suits dust remover's structural improvement and chemical modification. Compared to non-phytochemical modifications, phytochemical modifications are more efficient and environmentally friendly. The development of dust remover structures concentrates primarily on the nozzle structure, nozzle diameter, the number of holes, and the distance, with the nozzle diameter being of particular significance. Sometimes, tweaking the nozzle structure does not yield significant efficiency improvements. However, supersonic nozzles demonstrate high efficiency and are likely to be a key area of future research. Experiments also investigated other factors' effects on coal mines' dust removal efficacy, including ventilation system, metamorphic degree of coal, and particle diameter. This review provides the latest dust removal technology information for coal mines. Intelligent technology provides the basis for experimental research on dust removal in coal mines. The future trends of experimental research in the coal mine dust control field include intelligent and automated dust control systems, comprehensive control of multiple pollutants, application of new materials and technologies, and interdisciplinary collaboration and cross-disciplinary research.

The Acceptability and Impact of a Video on Compassion Focused Therapy as a Psycho-Educative Tool to Deepen Awareness around Voice-Hearing

In the compassion focused therapy (CFT) model of voice-hearing, a distressing relationship with voices is thought to be influenced by evolved threat-protection patterns, which are activated and attuned by socially threatening experiences, such as being harmed by others, as well being shamed, stigmatised, invalidated, and excluded. Therefore, the CFT approach is particularly interested in the role of voice-hearers’ relationships with others and self, as well as their social context of family/friends, professionals/services, and the wider community. This article reports on the impact of a 5-minute film, ‘Compassion for Voices’, which aimed to engage a general public audience with the compassionate approach to relating with voices, with potential as a therapeutic, educational, and de-stigmatising tool. One hundred and thirty-seven people responded to an anonymous online public feedback survey asking about their perceived impact of this film, amongst whom were 20 voice-hearers, 30 family/friends of voice-hearers, and 87 who work with voice-hearers. Quantitative data were gathered from responders’ perceived impact ratings (yes/no) in several different domains, and qualitative feedback data were analysed using content analysis by an independent research team. Over 98% of total responders thought the film has, or could potentially have, an impact on people’s health and welfare, and within the subsamples of both family/friends and the people who directly work with voice-hearers, this was 100%. The qualitative data revealed main impact themes around <em>knowledge and education</em>, <em>changes of attitudes or approaches to voice-hearing</em>, and <em>validation of people’s lived experience</em>. Although there are limitations to the online survey method, and therefore caution around what conclusions can be drawn, this study demonstrated a clear value and perceived impact among the sample who responded. This offers support for the use of video tools for social and community interventions, which is very much in keeping with the theoretically- and empirically- supported aims of CFT.

Inner Peace: Evaluating a Complementary Program Promoting Intra-Personal Peace at Adelaide Women's Prison, Australia.

The Peace Education Program, created in 2012, is a complementary program with potential to supplement official rehabilitation interventions offered in correctional centers. The program promotes "inner peace" as an innate and universal human resource, but whilst inner peace is a key concept in positive psychology and the Good Lives Model, there is a paucity of research regarding how to operationalize and evaluate this concept. The program had not previously been the subject of independent theoretically-informed research. Drawing on a mixed methods study conducted in Adelaide Women's Prison, this article explores the impact of the program on participants' learning regarding inner peace. Participants reported a greater understanding about inner peace, which they described as contributing to a stronger sense of their identity, enhanced self-esteem and increased self-regulation skills, resulting in reductions in impulsivity and reactive aggression. The quantitative data indicated there was a significant increase in participants' subjective ratings of inner peace before the program (M = 12.08) and post-program completion (M = 14.00) (p < .001). Growth in affect-regulation and anger-management skills may contribute to reductions in offending.

A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein.

The COVID-19 pandemic has underscored the critical need for the advancement of diagnostic and therapeutic platforms. These platforms rely on the rapid development of molecular binders that should facilitate surveillance and swift intervention against viral infections. In this study, we have evaluated by three independent research groups the binding characteristics of various published RNA and DNA aptamers targeting the spike protein of the SARS-CoV-2 virus. For this comparative analysis, we have employed different techniques such as biolayer interferometry (BLI), enzyme-linked oligonucleotide assay (ELONA), and flow cytometry. Our data show discrepancies in the reported specificity and affinity among several of the published aptamers and underline the importance of standardized methods, the impact of biophysical techniques, and the controls used for aptamer characterization. We expect our results to contribute to the selection and application of suitable aptamers for the detection of SARS-CoV-2.

Using Implementation Research to Inform Scaling of Parenting Programs: Independently Conducted Case Studies from Zambia and Bhutan.

Two case studies of parenting programs for parents of children 0 to 36 months of age, developed and implemented by Save the Children/Ministry of Health/Khesar Gyalpo University in Bhutan and UNICEF Zambia, were conducted by an independent research group. The focus was on how program delivery and scale-up were revised on the basis of feedback from implementation research. Feedback on workforce delivery quality was based on observations of deliveries using a monitoring form, as well as survey and interview data collected from the workforce. In-depth interviews with the resource team during the fourth year of implementation revealed how the feedback was used to address horizontal and vertical scaling. Delivery quality was improved in some cases by revising the delivery manual, offering refresher courses, and instituting regular monitoring. Scaling challenges in Zambia included slow progress with regard to reaching families in the two districts, which they addressed by trialing group sessions, and stemming workforce attrition. The challenges in Bhutan were low attendance and reducing the workload of providers. Vertical scaling challenges for both countries concerned maintaining demand through continuous advocacy at community and government levels to sustain financing and to show effectiveness in outcomes.

Insulin regulation of regional lipolysis in upper-body obese and lean humans.

Upper body obesity (UBO) results in insulin resistance with regards to free fatty acid (FFA) release; how this differs by fat depot and sex between UBO and lean adults is unknown. We tested the hypothesis that insulin suppression of FFA release from the splanchnic bed, leg fat and upper body non-splanchnic (UBNS) adipose tissue would be impaired in UBO. Fourteen UBO (7 men, 7 women) and 14 healthy, normal weight (7 men, 7 women) volunteers participated in studies that included femoral artery, femoral vein and hepatic vein catheterization. We then measured leg and splanchnic plasma flow as well as FFA kinetics (using isotopic tracers) under overnight fasting, low- and high-dose insulin infusion using the insulin clamp technique. We found the expected insulin resistance in UBO; the most quantitatively important difference between UBO and lean adults was greater FFA release from UBNS adipose tissue when plasma insulin concentrations are in the post-prandial, physiological range. There were obesity, but not sex differences in the regulation of splanchnic FFA release and sex differences in the regulation of leg FFA release. Reversing the defects in insulin-regulated UBNS adipose tissue FFA release would have the greatest impact on systemic FFA abnormalities in UBO. (not applicable)Funding: These studies were supported by grants DK45343 and DK40484 from the U.S. Public Health Service, and the Novo Nordic Foundation (grant numbers NNF18OC0031804 and NNF16OC0021406) and the Independent Research Fund Denmark (grant number 8020-00420B).

Increasing Equitable Access to Home Visiting: An Independent Implementation Study of Family Connects

Increasing Equitable Access to Home Visiting: An Independent Implementation Study of Family Connects

Progressive Resistance Training or Neuromuscular Exercise for Hip Osteoarthritis : A Multicenter Cluster Randomized Controlled Trial.

Exercise is recommended as first-line treatment for patients with hip osteoarthritis (OA). However, randomized controlled trials providing evidence for the optimal exercise type are lacking. To investigate whether progressive resistance training (PRT) is superior to neuromuscular exercise (NEMEX) for improving functional performance in patients with hip OA. Multicenter, cluster-randomized, controlled, parallel-group, assessor-blinded, superiority trial. (ClinicalTrials.gov: NCT04714047). Hospitals and physiotherapy clinics. 160 participants with clinically diagnosed hip OA were enrolled from 18 January 2021 to 28 April 2023 and randomly assigned to PRT (n = 82) or NEMEX (n = 78). Twelve weeks of PRT or NEMEX with 2 supervised 60-minute group sessions each week. The PRT intervention consisted of 5 high-intensity resistance training exercises targeting muscles at the hip and knee joints. The NEMEX intervention included 10 exercises and emphasized sensorimotor control and functional stability. The primary outcome was change in the 30-second chair stand test (30s-CST). Key secondary outcomes were changes in scores on the pain and hip-related quality of life (QoL) subscales of the Hip Disability and Osteoarthritis Outcome Score (HOOS). The mean changes from baseline to 12-week follow-up in the 30s-CST were 1.5 (95% CI, 0.9 to 2.1) chair stands with PRT and 1.5 (CI, 0.9 to 2.1) chair stands with NEMEX (difference, 0.0 [CI, -0.8 to 0.8] chair stands). For the HOOS pain subscale, mean changes were 8.6 (CI, 5.3 to 11.8) points with PRT and 9.3 (CI, 5.9 to 12.6) points with NEMEX (difference, -0.7 [CI, -5.3 to 4.0] points). For the HOOS QoL subscale, mean changes were 8.0 (CI, 4.3 to 11.7) points with PRT and 5.7 (CI, 1.9 to 9.5) points with NEMEX (difference, 2.3 [CI, -3.0 to 7.6] points). Participants and physiotherapists were not blinded. In patients with hip OA, PRT is not superior to NEMEX for improving functional performance, hip pain, or hip-related QoL. Independent Research Fund Denmark.

Unravelling the process of idea generation and assessment during the PhD trajectory: A case study approach

AbstractThe three missions of universities are education, research, and knowledge/technology transfer. At the micro‐level of the research and knowledge/technology transfer mission, we position researchers, as individuals who decided to pursue a scientific career in academia, with the PhD as the starting point. While existing literature acknowledges the supervisor's significance during this process from dependency to autonomy, this paper advocates for a closer examination of external factors such as the network, supervisor's experience, and work environment in idea generation. Ideas in this context encompass both curiosity‐driven and entrepreneurial concepts, often evolving from one to the other. Our research builds upon the theory of opportunity identification, drawing parallels between ideas and opportunities. The research asserts that PhD students primarily rely on their networks for idea generation due to limited prior knowledge and experience. Our findings underscore the dynamic interplay between PhD students, supervisors, and networks in the process of idea generation, advancing a comprehensive framework encapsulating the multifaceted influences on the trajectory from idea generation to execution in the context of PhD education. The framework is based on empirical evidence from a qualitative case study comprising 16 PhD students in a European H2020 project in the field of Photonics, illuminating the intricate relationship between supervisors' orientations (entrepreneurial or curiosity‐driven) and the types of ideas generated by PhD students. Practical implications highlight the need for tailored support and resources to foster independent research capabilities among PhD students, considering individual variations in supervisory support and networking opportunities.

Abstract CT129: A phase 1 dose escalation study of a novel coupled CAR T cell therapy, GCC19CART, for patients with metastatic colorectal cancer

Abstract Background: GCC19CART, the first clinical candidate from the CoupledCAR solid tumor platform, is designed to overcome the limitations of conventional CAR T-cells in solid tumor malignancies by pairing solid tumor CAR T-cells with CD19-targeting CAR T-cells to amplify the proliferation and activation of the solid tumor CAR T component. GCC19CART targets guanylate cyclase-C (GCC), which is reported to be expressed in the metastatic lesions of 70%-80% of subjects with colorectal cancers and largely restricted to the intestinal tract. A Phase 1 investigator-initiated clinical trial conducted in China showed preliminary efficacy with an overall response rate (ORR) at dose level 1 (1x106 CAR T-cells/kg) of 15.4% ORR (2/13) and 50% ORR (4/8) in dose level 2 (2x106 CAR T-cells/kg). Common side effects included cytokine release syndrome (CRS) and diarrhea/colitis. Immune effector cell-associated neurotoxicity syndrome (ICANS) was seen in a smaller proportion of patients. A phase 1 study was initiated in the United States in August 2022 for patients with metastatic colorectal cancer refractory to standard of care chemotherapy. As of a data cutoff on ​November 1, 2023, 4 subjects have been treated in the initial dose level. Methods: Subjects were initially screened for GCC expression; this requirement was later discontinued when immunohistochemistry studies revealed that the frequency of positive GCC expression exceeded 95%. Eligible subjects underwent leukapheresis, a single dose of lymphodepleting chemotherapy (fludarabine 30mg/m2 and cyclophosphamide 300mg/m2) 3 days prior to infusion, and then administration of a single infusion of GCC19CART. Responses were assessed by RECIST v1.1 by site investigator review and an independent third-party imaging contract research organization. Results: 4 subjects have been dosed at level 1 (1x106 cells/kg) and completed the DLT period at the time of data cutoff. The most common adverse events were CRS in 4/4 subjects (Grade 1: 2/4 (50%) or Grade 2: 2/4 (50%)) and diarrhea in 3/4 subjects (Grade 1: 1/4 (25%), Grade 2: 1/4 (25%), or Grade 3: 1/4 (25%)). Three out of four patients had a mild tremor (Grade 1) that resolved with corticosteroids and no other evidence of neurotoxicity. The combined overall response rate (ORR) was 50% (2/4) by independent review. Two subjects demonstrated a partial response (PR) while 1 additional subject had partial metabolic response (PMR) on PET/CT with stable disease (SD) and 1 patient had progressive disease per RECIST 1.1. Per site investigator review, the ORR was 25%, with 1 confirmed PR and 3 SD assessed as best response. The median PFS was 3.8 months in the dose level 1 group. Conclusions: Preliminary results demonstrate that GCC19CART has meaningful clinical activity and an acceptable safety profile in refractory metastatic colorectal cancer. This trial is ongoing and updated data will be presented, including from patients treated at dose level 2 (2x106 CAR T-cells/kg). Clinical trial information: NCT05319314. Citation Format: Bridget P. Keenan, Christopher H. Lieu, Marwan Fakih, Dongqi Chen, Lucy Lu, Eric Rowinsky, Victor Lu, Lei Xiao, Alan P. Venook, Benjamin Schlechter. A phase 1 dose escalation study of a novel coupled CAR T cell therapy, GCC19CART, for patients with metastatic colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT129.

The COVID-19 Vaccine Safety Research Center: a cornerstone for strengthening safety evidence for COVID-19 vaccination in the Republic of Korea.

The COVID-19 Vaccine Safety Research Committee (CoVaSC) was established in November 2021 to address the growing need for independent, in-depth scientific evidence on adverse events (AEs) following coronavirus disease 2019 (COVID-19) vaccination. This initiative was requested by the Korea Disease Control and Prevention Agency and led by the National Academy of Medicine of Korea. In September 2022, the COVID-19 Vaccine Safety Research Center was established, strengthening CoVaSC's initiatives. The center has conducted various studies on the safety of COVID-19 vaccines. During CoVaSC's second research year, from September 29, 2022 to July 19, 2023, the center was restructured into 4 departments: Epidemiological Research, Clinical Research, Communication & Education, and International Cooperation & Policy Research. Its main activities include (1) managing CoVaSC and the COVID-19 Vaccine Safety Research Center, (2) surveying domestic and international trends in AE causality investigation, (3) assessing AEs following COVID-19 vaccination, (4) fostering international collaboration and policy research, and (5) organizing regular fora and training sessions for the public and clinicians. Causality assessments have been conducted for 27 diseases, and independent research has been conducted after organizing ad hoc committees comprising both epidemiologists and clinical experts on each AE of interest. The research process included protocol development, data analysis, interpretation of results, and causality assessment. These research outcomes have been shared transparently with the public and healthcare experts through various fora. The COVID-19 Vaccine Safety Research Center plans to continue strengthening and expanding its research activities to provide reliable, high-quality safety information to the public.

Nudibranch molluscs of Sakhalin Island, Northwestern Pacific: new records and descriptions of two new species

In this paper we investigate a collection of nudibranch molluscs from Sakhalin Is. by means of integrative taxonomy, including morphological analyses, and molecular data from the cytochrome c oxidase subunit I, 16S rRNA, Histone H3 and 28S rRNA markers. Material used in this study was collected during two independent research programs: the expedition of the R/V “Akademic Oparin” (Russia) to the Sea of Okhotsk, July 2019 at depths of 38–282 m, and the survey of Cape Crillon biodiversity in August 2023, at depths of 0.5–20 m. Our integrative results revealed clear cases of the unknown diversity within some groups of the nudibranch molluscs. Among the dorid nudibranchs, the new species Adalaria boussoleana sp. nov. is described and differs in morphological and molecular characters from other species of the genus. Also, among specimens of the genus Cadlina we have detected two genetically distinct groups, one is close to C. umiushi and another group likely represents a new species for science. Their morphology is similar to the diagnosis of C. umiushi and may represent a case of true cryptic diversity. Among the cladobranch molluscs our results revealed a new species of the genus Cuthonella described herein under the name Cuthonella anastasia sp. nov. Four species are recorded for Sakhalin Is. waters for the first time: Cadlina umiushi, Onchimira cavifera, Eubranchus rupium and E. alexeii. After this paper, the total nudibranch fauna of Sakhalin Is. includes 21 species. Although we have limited numbers of nudibranch species in Sakhalin waters due to low sampling effort, a comparison of the biogeographic affinities of species from different regions is consistent with the presence of a biogeographic boundary between northeastern and southwestern Sakhalin.

The relationship between health insurance and economic performance: an empirical study based on meta-analysis.

Health insurance stands as a pivotal facet of social wellbeing, with profound implications for the overarching landscape of economic development. The existing research, however, lacks consensus on the relationship between health insurance and economic performance and provides no evidence about the magnitude of the correlation. This lack of information seriously impedes the high-quality development of the healthcare system. Therefore, to scientifically elucidate the relationship between the two, this study involved a meta-analysis, analyzing 479 effect values derived from 34 independent research samples. The results reveal a strongly positive correlation between health insurance and economic performance [r = 0.429, 95% CI = (0.381, 0.475)]. Findings show that health insurance in developed countries more effectively fosters economic performance than in developing countries. Moreover, public health insurance exerts a stronger promoting effect on economic performance than commercial health insurance. The relationship between health insurance and economic performance is moderated by data type, research method, country of sample origin, literature type, journal impact factor, publication year, type of health insurance, and the research populations. Based on meta-analysis, this study not only scientifically responds to the controversy of the relationship between health insurance and economic performance, and the magnitude of a correlation, but also further reveals the inner conduction mechanism between the two. Our research findings are meaningful for policymakers to choose an appropriate healthcare strategy according to their unique attributes, propelling sustainable economic development.